" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.
So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.
Take it for the first time when you will be at home for a few hours in case it makes you sleepy.
Bender, Ph D, of National Jewish Medical and Research Center in Denver.
"The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.
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